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Abstract #2025

Accelerated second-order motion-compensated diffusion imaging with phase-contrast for regional cerebral blood flow quantification

Naoki Ohno1, Tosiaki Miyati1, Suzuka Nakatani2, Noam Alperin3, Yu Ueda4, and Satoshi Kobayashi1
1Kanazawa University, Kanazawa, Japan, 2Tokai University Hospital, Isehara, Japan, 3University of Miami, Miami, FL, United States, 4Philips Japan, Tokyo, Japan

Synopsis

Keywords: IVIM, IVIM, Perfusion, Diffusion, Phase-contrast, rCBF

Motivation: Regional cerebral blood flow (rCBF) quantification using second-order motion-compensated diffusion imaging with phase-contrast (2nd-MC-DIP) achieves accurate measurements; however, long acquisition time limits its clinical implementation.

Goal(s): To reduce the acquisition time of 2nd-MC-DIP using optimal b-value selection while maintaining accurate rCBF quantification.

Approach: We compared rCBF values between conventional (11 b-values) and accelerated (4 optimally selected b-values) 2nd-MC-DIP in healthy volunteers, validating against arterial spin labeling (ASL).

Results: The accelerated protocol showed no significant differences in rCBF values compared with the conventional 11-point protocol and demonstrated significant positive correlations with ASL, achieving equivalent accuracy with a 63% reduction in acquisition time.

Impact: Optimized b-value selection achieved a three-fold reduction in acquisition time, making 2nd-MC-DIP practical for clinical use in accurate rCBF quantification.

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Keywords