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Abstract #2032

IVIM-MRI-Derived Robustness Index for Evaluating ADT Response and Hypoxia in Prostate Cancer

Yen-Peng Liao1, Yan Dai2, Neil Desai1, Xun Jia3, and Jie Deng1,2
1Radiation Oncology, UT Southwestern Medical Center, Dallas, TX, United States, 2Biomedical Engineering, UT Southwestern Medical Center, Dallas, TX, United States, 3Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, MD, United States

Synopsis

Keywords: IVIM, IVIM, Hypoxia,Androgen Deprivation Therapy,Prostate Cancer,Treatment Response

Motivation: Our previous study established a Robustness Index (Ri) that optimally combines IVIM-MRI parameters with enhanced stability for treatment response and hypoxia assessment.

Goal(s): To investigate the clinical utility of Ri (≈ 2f + Dt) in assessing ADT-induced changes and hypoxic environment in prostate cancer.

Approach: We compared Ri in ADT-treated and untreated prostate cancer tissues, evaluating its ability to detect treatment changes and correlate with hypoxia-related gene expression.

Results: Ri showed superior discriminative power (p=0.029) compared to conventional parameters (ADC: p=0.065; Dt: p=0.26), and IQR of Ri demonstrated significant correlation with hypoxia hallmark scores, indicating potential for both treatment monitoring and hypoxia assessment.

Impact: This optimized IVIM parameter Ri can be used for detection of ADT response and assessment of tumor hypoxic environment in prostate cancer prior to radiation therapy, providing a valuable tool for evaluating treatment effects on the tumor microenvironment.

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