Abstract #2037

Microstructural and physiological changes in SARS-CoV-2 pregnancy infection by two perfusion IVIM model

Alessandra Maiuro^1,2, Claudia Cutonilli³, Giuseppe Rizzo⁴, Maria Grazia Porpora⁴, Carlo Catalano³, Antonella Giancotti⁴, Lucia Manganaro³, and Silvia Capuani^1,2

¹Physics, Sapienza University of Rome, Rome, Italy, ²ISC, CNR, ROMA, Italy, ³Radiological, Oncological and Pathological Sciences, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy, ⁴Maternal and Child Health and Urological Sciences, Policlinico Umberto I, Sapienza University of Rome, ROMA, Italy

Synopsis

Keywords: IVIM, IVIM, Perfusion, Diffusion, COVID-19, Microstructural damage

Motivation: Investigating possible placental damage due to viruses, using the new two-perfusion-IVIM model.

Goal(s): Previous studies conducted with IVIM have highlighted only microstructural placental damage due to SARS-CoV-2. We hypnotized also vascular damage related to perfusion. Therefore, we used the two-perfusion-IVIM model.

Approach: We quantified IVIM and two-perfusion-IVIM parameters in vivo, in healthy pregnant and pregnant women affected by SARS-CoV-2.

Results: The slowest perfusion fraction, f2, of the two-perfusion-IVIM, the one related to trophoblasts, is significantly lower in subjects affected by SARS-CoV-2 compared to healthy subjects, suggesting an impairment of the exchange between mother and fetus, not detectable by IVIM.

Impact: Two-perfusion-IVIM model has highlighted a trophoblast perfusion impairment in SARS-CoV-2 placentas not visible by the f parameter of IVIM. Two-perfusion-IVIM opens the possibility of in-depth investigations of different viruses’ infections on placental tissues.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.