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Abstract #2049

MR-Guided Vagal Cryoablation for the Treatment of Obesity in a Canine Animal Model – Preliminary Results

Arun Kamireddy1, Clifford R Weiss1, Eun Ji Shin1, Cory Brayton1, Robert A Anders1, and Dara L Kraitchman1
1Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: MR-Guided Interventions, MR-Guided Interventions

Motivation: To explore MR-guided vagal cryoablation as a minimally invasive option for obesity management.

Goal(s): To evaluate safety, feasibility, and efficacy of MR-guided vagal cryoablation assessing its impact on weight and metabolism in an obese canine model.

Approach: Three healthy dogs were used to develop workflow. In chronic studies, two cohorts of obese dogs underwent MR-guided vagal cryoablation. Cohort 1 received excess calories both pre- and post-procedure. Cohort 2, currently ongoing, received excess calories only pre-procedure, simulating lifestyle modification post-procedure.

Results: Cryoablation was technically successful in all dogs. Cohort 1 showed 5.3% weight gain post-procedure with no significant changes in fat percentage.

Impact: Preliminary results indicate MR-guided vagal cryoablation is feasible and safe but may require adjunctive therapies for effective obesity management. Future studies could enhance its efficacy as part of a multimodal treatment approach.

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