Meeting Banner
Abstract #2057

Assessing Response to Neoadjuvant Radiotherapy and Targeted Therapy in Soft Tissue Sarcoma by IVIM-DWI-derived Tumor Habitat Characteristics

Xin Wen1, Jiuming Jiang1, SiCong Wang2, Yueluan Jiang3, Yang Song4, Ningning Lu5, and Meng Li1
1Department of Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Bei Jing, China, 2GE Healthcare China, Bei Jing, China, 3MR Research Collaboration, Siemens Healthineers, Bei Jing, China, 4MR Research Collaboration Team, Siemens Healthineers Ltd., Shang Hai, China, 5Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Bei Jing, China

Synopsis

Keywords: Muscle, Diagnosis/Prediction, Soft Tissue Sarcoma, IVIM, Tumor Habitat Characteristics, Neoadjuvant Radiotherapy

Motivation: Soft tissue sarcoma (STS) can be treated with neoadjuvant radiotherapy (neo-RT) and targeted therapy. However, neo-RT raises wound complication risks, necessitating early treatment efficacy assessment for better clinical planning.

Goal(s): To evaluate the pathological response in STS patients undergoing neo-RT and targeted therapy using sub-regional Intravoxel Incoherent Motion (IVIM) parameters.

Approach: This prospective study included 21 patients with STS who underwent IVIM imaging. Quantitative IVIM parameters were extracted and analyzed with logistic regression to develop predictive models for treatment response.

Results: The combined IVIM model showed a significantly higher AUC (0.952 [95%CI: 0.761-0.999]) in predicting treatment response compared to all individual parameter models.

Impact: This study demonstrates that IVIM-based models offer a high-accuracy, non-invasive diagnostic approach for early assessment of treatment response in neo-RT and targeted therapy for STS, supporting personalized treatment strategies.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords