Meeting Banner
Abstract #2060

Integrating MRI Delta-radiomics and Transcriptomics to Assess Neoadjuvant Radiotherapy plus Targeted Therapy in Soft Tissue Sarcoma

Lei Miao1, LiTing Yang2, JiuMing Jiang3, SiCong Wang4, Meng Li3, Xiao Li1, and NingNing Lu5
1Interventional Therapy, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 2State Key Laboratory of Molecular Oncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 3Radiology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 4GE Healthcare China, Beijing, China, 5Radiation Oncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Synopsis

Keywords: Other Musculoskeletal, Treatment Response, soft tissue sarcoma; Neoadjuvant radiation therapy; Targeted Therapy

Motivation: The complexity and heterogeneity of soft tissue sarcomas (STS) create challenges in personalized treatment, underscoring the need for tools that can reveal tumor characteristics and their biological implications.

Goal(s): To evaluate the ability of MRI-based Delta-radiomics in classifying STS patients and explore its association with transcriptomic changes and immune microenvironment characteristics.

Approach: Prospective phase II trial with 84 STS patients, utilizing MRI for radiomic feature extraction and transcriptomic analysis to correlate gene expression with treatment response.

Results: Delta-radiomics stratified patients into distinct clusters, revealing significant correlations with gene expression profiles and immune response patterns, highlighting a comprehensive approach to treatment stratification in STS.

Impact: The integration of radiomics and transcriptomics in this study has revolutionized the understanding of STS, providing a non-invasive approach to uncover the genetic basis of disease. This fusion offers a comprehensive view of disease mechanisms, which can enhance personalized treatment.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords