Keywords: Other Musculoskeletal, Diffusion Analysis and Visualization
Motivation: Clinical applications of time-dependent diffusion MRI (td-dMRI) for differentiating benign and malignant bone tumors are rarely explored.
Goal(s): To investigate the utility of td-dMRI in distinguishing between malignant and benign bone tumors using ADC obtained from oscillating gradient spin-echo (OGSE) and pulsed gradient spin echo (PGSE) diffusion MRI sequences with different effective diffusion times.
Approach: ADCOGSE and ADCPGSE values of fifty patients were compared using the independent samples t-test. ROC curve was used to assess the diagnostic performance in differentiation between benign and malignant lesions.
Results: The ADC values obtained by td-dMRI show potential diagnostic values in differentiating benign and malignant bone tumors.
Impact: The td-dMRI technology links the diffusion-time dependence of water diffusion in living cells to specific microstructural parameters. ADC values derived from td-dMRI at different gradient oscillation frequencies showed potential diagnostic value for clinical differentiation between benign and malignant bone tumors.
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