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Abstract #2062

Time-Dependent Diffusion MRI to Distinguish Malignant From Benign Bone Tumors

Ying Li 1, Cuiping Ren1, Jingliang Cheng1, Yong Zhang1, Wenhua Zhang1, and Liangjie Lin2
1The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 2Clinical & Technical Support, Philips Healthcare, Beijing, 100102, China, Beijing, China

Synopsis

Keywords: Other Musculoskeletal, Diffusion Analysis and Visualization

Motivation: Clinical applications of time-dependent diffusion MRI (td-dMRI) for differentiating benign and malignant bone tumors are rarely explored.

Goal(s): To investigate the utility of td-dMRI in distinguishing between malignant and benign bone tumors using ADC obtained from oscillating gradient spin-echo (OGSE) and pulsed gradient spin echo (PGSE) diffusion MRI sequences with different effective diffusion times.

Approach: ADCOGSE and ADCPGSE values of fifty patients were compared using the independent samples t-test. ROC curve was used to assess the diagnostic performance in differentiation between benign and malignant lesions.

Results: The ADC values obtained by td-dMRI show potential diagnostic values in differentiating benign and malignant bone tumors.

Impact: The td-dMRI technology links the diffusion-time dependence of water diffusion in living cells to specific microstructural parameters. ADC values derived from td-dMRI at different gradient oscillation frequencies showed potential diagnostic value for clinical differentiation between benign and malignant bone tumors.

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Keywords