Keywords: Other Musculoskeletal, biomarkers, Soft Tissue Sarcoma, DWI, IVIM, DCE
Motivation: Despite standardized neoadjuvant radiation therapy (NRT) protocols in soft tissue sarcomas (STS), treatment response varies significantly between patients, yet lacks reliable non-invasive monitoring methods during treatment.
Goal(s): To identify distinct radiation therapy response patterns using multiparametric MRI for early response monitoring.
Approach: Prospective analysis of 20 STS patients using standardized quantitative MRI protocol at three timepoints during NRT.
Results: ADC was the only parameter showing significant temporal evolution during treatment (p<0.001). Statistical clustering analysis identified three distinct, highly stable response patterns with significant inter-cluster differences in ADC (p=0.001) and Ktrans (p=0.003).
Impact: This analysis reveals distinct biological response phenotypes during radiation therapy that can be identified through non-invasive imaging. These findings could enable early response prediction and therapy adaptation, potentially improving patient outcomes through personalized treatment approaches.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords