Abstract #2070

Longitudinal changes of resting state functional connectivity in high-contact sports

Mahta Karimpoor¹, Yixin Wang¹, Hossein Moein Taghavi¹, Marios Georgiadis¹, Rastko Ciric¹, Sohrab Sami¹, Brian Mills¹, Jessica Towns¹, Nicholas Cecchi¹, Victoria Ortega¹, Charles Liu², John Van Horn³, Max Wintermark⁴, Maged Goubran⁵, Gerald Grant⁶, David Camarillo¹, and Michael Zeineh¹

¹Stanford, Stanford, CA, United States, ²USC, Los Angeles, CA, United States, ³University of Virginia, Charlottesville, VA, United States, ⁴MD Anderson, Houston, TX, United States, ⁵University of Toronto, Toronto, ON, United States, ⁶Duke, Durham, NC, United States

Synopsis

Keywords: Traumatic Brain Injury, Brain Connectivity

Motivation: Repetitive contact sports head trauma poses cognitive decline risks.

Goal(s): To assess whether high-contact sports exposure leads to longitudinal changes in resting-state functional connectivity (rsFC) and associated cognitive performance longitudinally.

Approach: Cognitive performance changes over time were assessed using ImPACT test scores. We acquired longitudinal rsFC and assessed a linear mixed-effects model to examine changes in rsFC by sport (high vs. low-contact), time, and their interaction.

Results: High-contact athletes showed reduced visual motor speed and memory longitudinally, and reduced integration between executive control and default mode, but stronger connectivity within networks associated with internally directed cognition and attention.

Impact: This research sheds light on how repetitive head impacts in contact sports affect brain connectivity over time and cognitive performance.

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