Keywords: Traumatic Brain Injury, Arterial spin labelling, concussion; glymphatic function; diffusion tensor imaging analysis along the perivascular space (DTI-ALPS); diffusion weighted- arterial spin labeling (DW-ASL); working memory
Motivation: This study seeks to understand how glymphatic dysfunction after concussion affects working memory, aiming to improve clinical tools for post-concussion cognitive assessment.
Goal(s): To investigate whether DTI-ALPS index and water permeability (kw) mediate the relationship between neural integrity (FA) and working memory (WMI) in concussion patients.
Approach: We used mediation analysis with DTI-ALPS and kw maps to assess glymphatic disruption in concussion patients, incorporating FA and WMI to model cognitive impacts.
Results: Both ALPS and kw mediated the FA-WMI relationship, with kw showing a stronger indirect effect. Findings suggest kw as a critical marker of cognitive dysfunction post-concussion.
Impact: This research highlights kw mapping as a crucial metric for assessing post-concussive glymphatic dysfunction, potentially aiding clinicians in predicting cognitive outcomes. The study suggests new directions for investigating neuroimaging biomarkers that link brain microstructure with cognitive function in TBI contexts.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords