Keywords: Adolescents, Multimodal, Mental Health
Motivation: Mental health in adolescence is an increasing concern, and early intervention of children at-risk of poor outcomes is key.
Goal(s): Our goal was to identify multimodal brain patterns that predict longitudinal behavioural and mental health measures.
Approach: Linked variations of cortical structure and white matter microstructure were assessed for relationships with longitudinal clinical measures.
Results: Together, macro and microstructural features within emotion regulation regions reliably predicted longitudinal symptoms of anxiety and depression. Deep gray matter volume and projection fibre microstructure predicted behavioural inhibition and sensation seeking in males, with differences between pairs of twins with and without self-injurious behaviour.
Impact: Our results demonstrate reliable brain patterns in childhood that predict primarily sub-clinical symptoms of anxiety and depression in a population-based sample. These findings motivate early supports and interventions for children identified at-risk of poor mental health trajectories.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords