Keywords: Neuro, Pediatric, infants; motor impairment; External hydrocephalus; Morphometric Similarity; transcriptomic approaches
Motivation: External hydrocephalus (EH) has been linked with motor impairment(MI) in 9.2% of cases. However, due to the natural developmental widening of the subarachnoid space in healthy infants, distinguishing pathological EH from benign conditions remains clinically challenging.
Goal(s): To improve differentiation between pathological and benign EH, facilitating earlier intervention in at-risk infants.
Approach: This study integrates morphometric similarity networks with transcriptomic data to explore structural and molecular alterations in infants with EH-related MI.
Results: We identified significant regional morphometric differences and synaptic signaling pathway enrichment, suggesting their involvement in the pathogenesis of EH-related MI.
Impact: Integrating neuroimaging and transcriptomics enhances understanding of EH-related MI pathogenesis, revealing potential imaging biomarkers for early diagnosis and novel targets for therapeutic intervention.
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