Meeting Banner
Abstract #2102

Lung Water Density (LWD) Imaging with MRI: Normative Values and Dependence on Field Strength, Pulse Sequence and Breathing Maneuver

Richard Thompson1, Christopher Keen2, Amy Kirkham3, Rachel Sherrington2, Richard Coulden1, Hefin Jones1, Peter Seres1, and Justin Grenier1
1Radiology and Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada, 2Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, 3Faculty of Kinesiology & Physical Education, University of Toronto, Toronto, ON, Canada

Synopsis

Keywords: Quantitative Imaging, Lung, UTE, pulmonary edema

Motivation: Lung water density (LWD) is an emerging quantitative measure of lung health; normal values and sources of bias are not established.

Goal(s): Determine normative values for LWD with consideration of age, sex, acquisition approach (pulse sequence, field strength) and breathing maneuver.

Approach: LWD maps were compared for different ultra-short TE pulse sequences (yarnball, Double-half-echo-Cartesian, Spiral-VIBE), field strengths (1.5T/2.89T) and breathing maneuvers (end-expiration(EE), end-inspiration(EI) or free breathing(FB)) (N=118 participants).

Results: Normative LWD values were ~26% for EE/FB studies and ~16% at EI, for all acquisition approach’s (~2% higher including the vascular pool), with slightly higher values for Spiral-VIBE. No age, sex, field strength dependence.

Impact: MRI-derived lung water density (LWD) is independent of age, sex and field-strength in healthy individuals but highly sensitive lung inflation (breathing maneuver) and with potential bias due to acquisition approach (k-space trajectory).

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords