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Abstract #2116

Robust variable flip angle T1-mapping by time optimal control

Christina Graf1,2, Alexander Jaffray1, Clemens Diwoky3, Armin Rund4, Stefan Steinerberger5, Andrew Yung6, and Alexander Rauscher1,2,6
1Department of Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, 2Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada, 3Institute of Molecular Biosciences, Karl-Franzens University Graz, Graz, Austria, 4Institute for Mathematics and Scientific Computing, Karl-Franzens University Graz, Graz, Austria, 5Department of Mathematics, University of Washington, Seattle, WA, United States, 6Department of Radiology, University of British Columbia, Vancouver, BC, Canada

Synopsis

Keywords: Quantitative Imaging, Quantitative Imaging

Motivation: Accurate T1-mapping is essential in MRI for insights into brain microstructure. While a variety of methods are available, inversion recovery is the gold standard, but requires lengthy acquisition times. Variable flip angle (VFA) T1-mapping offers a faster alternative, but is highly sensitive to B1+-field imperfections.

Goal(s): To enhance the accuracy of VFA T1-mapping with robust excitation pulses by time-optimal control.

Approach: Excitation pulses were designed using optimal control, followed by VFA-mapping in phantom. Results were compared against VFA T1-values obtained with block pulses and inversion recovery as the ground truth.

Results: VFA T1-mapping with optimal control pulses demonstrates improved accuracy over block pulses.

Impact: The advancement in VFA T1-mapping using robust excitation pulses designed by time-optimal control reduces scan time as no additional acquisition of B1+-maps is necessary, and it minimizes potential errors associated with inaccuracies in the B1+-maps and their correction.

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Abstract

Keywords