Keywords: Breast, Drugs
Motivation: Current radiogenomics studies are limited in linking image phenotypes with genomic phenotypes, and their clinical translation value remains inadequately explored.
Goal(s): Define novel breast cancer subtype using only image-associated genes and evaluate its prognostic and therapeutic importance.
Approach: Extract a comprehensive image profile, identify image-associated genes, and define an image-inspired genomic subtype (I2G-C).
Results: The new subtype, I2G-C, is distinct from traditional subtypes, characterized by unique immune and repair functions. I2G-C shows significant predictive value for patients receiving anti-HER2 therapies and identifies high-risk patients in terms of disease-free survival.
Impact: This study advances radiogenomics by demonstrating functional MRI-guided identification of new breast cancer subtypes, highlighting its potential in clinical applications.
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