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Abstract #2131

Optimizing DCE-MRI Interpretation to Improve Tumor Extent Assessment and Margin Negativity in Breast-Conserving Surgery for Lobular Carcinoma

Nariya Cho1,2 and Heera Yoen3
1Radiology, Seoul National University Hospital, Seoul, Korea, Republic of, 2Radiology, Seoul National University College of Medicine, Seoul, Korea, Republic of, 3Seoul National University Hospital, Seoul, Korea, Republic of

Synopsis

Keywords: Breast, Tumors

Motivation: Preoperative breast MRI has not reliably improved negative margin achievement in breast-conserving surgery for invasive lobular carcinoma.

Goal(s): This study aims to determine the optimal DCE-MRI phase and assess the impact of including mass or non-mass enhancements for accurate tumor extent assessment in lobular carcinoma.

Approach: We analyzed correlation coefficients between tumor sizes on histopathology and DCE-MRI, evaluating variations by lesion type (mass vs. non-mass), imaging phase (early vs. delayed), and cancer type (lobular vs. ductal).

Results: Lobular carcinoma was generally underestimated on MRI, with the highest correlation observed when both lesion types were included, especially during the delayed phase at DCE-MRI.

Impact: Incorporating both mass and non-mass enhancements in the delayed phase of DCE-MRI could improve preoperative assessment accuracy for lobular carcinoma, helping surgeons achieve negative resection margins and potentially reducing reoperation rates in breast-conserving surgery.

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