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Abstract #2133

Classification of HER2-zero and HER2-low and Prediction of Progression in Triple Negative Breast Cancer Using MRI Features

Jiejie Zhou1, Yang Zhang2, Yan-Lin Liu2, Jeon-Hor Chen2, Meihao Wang3, and Min-Ying Su2
1Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China, 2University of California, Irvine, CA, United States, 3The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

Synopsis

Keywords: Breast, Breast

Motivation: Triple-negative breast cancer (TNBC) is more aggressive than other molecular subtypes, and finding new biomarkers for targeted therapy and stratification of progression risk would be helpful.

Goal(s): To evaluate MRI features between HER2-zero and HER2-low, and between progressed vs. non-progressed TNBC patients.

Approach: MRI features were reviewed by radiologists based on BI-RADS lexicon.

Results: 85/126 (67%) were identified as HER2-zero and 41 (33%) as HER2-low. No MRI features showed a significant difference between HER2-zero vs HER2-low. Fourteen of 126 (11%) patients showed progression (local, regional progression or distant metastasis), and they have more aggressive finding features and higher stages.

Impact: TNBC had negative ER, PR, and HER2, which was defined as immunohistochemical staining 0, 1+, or 2+ with negative FISH, but currently, HER2-low may receive anti-HER2 drug conjugates. Finding imaging biomarkers may help in precision treatment and understanding progression risk.

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