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Abstract #2139

MRI-based Intratumoral and Peritumoral Radiomics for Assessing Deep Myometrial Invasion with Early-Stage Endometrioid Adenocarcinoma

Jing Yang1, Qiu Bi1, Yunzhu Wu2, and Yang Song2
1The First People’s Hospital of Yunnan Provence, Kunming, China, 2MR Research Collaboration Team, Siemens Healthineers Ltd, beijing, China

Synopsis

Keywords: Cancer, MR Value, Endometrial carcinoma; Deep Myometrial invasion; MRI; Radiomics; Peritumoral

Motivation: Accurate assessment of deep myometrial invasion (DMI) in endometrial cancer (EC) is crucial for treatment planning and prognosis.

Goal(s): This study aimed to develop radiomics models utilizing both intratumoral and peritumoral features to predict DMI in early-stage EC.

Approach: A cohort of 459 patients underwent magnetic resonance imaging (MRI), and radiomics features were extracted from various imaging sequences. Multiple logistic regression models were constructed and validated.

Results: The multimodal MRI-based radiomics model from the intratumoral and peritumoral regions expanded by 5 mm proved optimal, with the stacking and ensemble models demonstrating similar performance at 5 mm expansion.

Impact: MRI-based radiomics models effectively predict deep myometrial invasion (DMI) in early-stage endometrioid adenocarcinoma (EAC). The multimodal radiomics model from the intratumoral and peritumoral regions expanded by 5 mm offers improved performance for detecting DMI in early-stage EAC.

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