Abstract #2145

Association of Radiomic Features of ADC and IVIM Placental maps with Clinical Outcomes in Normal and Hypertensive Pregnancies

Christina L. Herrera^1,2, Quyen N. Do³, Yin Xi³, David Owen^1,2, Baowei Fei^3,4,5, Catherine Y. Spong^1,2, Diane M. Twickler^2,3, and Matthew A. Lewis³

¹Department of Obstetrics and Gynecology, UT Southwestern Medical Center, Dallas, TX, United States, ²Department of Obstetrics and Gynecology, Parkland Health, Dallas, TX, United States, ³Radiology, UT Southwestern Medical Center, Dallas, TX, United States, ⁴Bioengineering and Computer Science, The University of Texas at Dallas, Richardson, TX, United States, ⁵Center for Imaging and Surgical Innovation, Richardson, TX, United States

Synopsis

Keywords: Placenta, Placenta

Motivation: Chronic hypertension (cHTN) is associated with adverse pregnancy outcomes. Radiomic analysis of MR images has the potential for early outcome prediction before the onset of clinical disease.

Goal(s): To correlate MR radiomic features derived from diffusion-weighted imaging (DWI) with maternal condition (cHTN) and pregnancy outcomes (preeclampsia with severe features, small for gestational age).

Approach: We performed ROI-based radiomic analysis on prospectively collected apparent diffusion coefficient (ADC) and intravoxel incoherent motion (IVIM) maps derived from the same DWI acquisition in normal and cHTN pregnancies.

Results: Several radiomic features significantly differed between normal and cHTN pregnancies.

Impact: Magnetic resonance imaging based radiomics of DWI data can distinguish pregnancies with normal from chronic hypertension pregnancies. Future work to correlate with pregnancy outcomes offers the potential for early risk assessment and improved obstetric management.

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