Abstract #2147

Predicting Preoperative Microsatellite Instability of Endometrial Cancer Using Amide Proton Transfer-Weighted Imaging and T2 Mapping

Lingyu Chang¹, Lianhua Cheng², Xinghua Xu², Liang Du¹, Ying Xu², Dmytro Pylypenko³, Tianyong Xu⁴, Xiangshui Meng¹, Dexin Yu², Qing Wang², and Fang Wang²

¹Qilu Hospital (Qingdao) of Shandong University, Qingdao city, Shandong province, China, ²Qilu Hospital of Shandong University, Jinan city, Shandong province, China, ³GE Healthcare, MR Research China, Beijing, China, ⁴GE Healthcare, MR Application China, Shanghai, China

Synopsis

Keywords: Uterus, Uterus, APTw Imaging, T2 Mapping, Endometrial Cancer, Microsatellite Instability

Motivation: Preoperative prediction of microsatellite instability (MSI) can provide a basis for personalized and precise treatment of endometrial cancer (EC).

Goal(s): This study aimed to determine the feasibility of amide proton transfer-weighted imaging (APTw) and T2 mapping parameters in assessing MSI in EC.

Approach: A total of 58 patients underwent preoperative MRI.

Results: The APTw and T2 values were significantly different in MSI and microsatellite stable (MSS) groups. The AUC value of the combined APTw and T2 mapping model was significantly higher than the individual parameters. Therefore, the combined model might be considered effective in assessing the MSI of EC preoperatively.

Impact: Our results demonstrate the promising potential of this combined model for the preoperative assessment of MSI in EA, which assists in formulating clinical therapeutic strategies and assessing prognosis.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.