Abstract #2153

3D distortion-free, T2 and ADC mapping in a single sequence for Quantitative Prostate MRI at 3T

Raphael Tomi-Tricot^1,2, Sarah McElroy^1,3, Yannik Ott^1,4, Omar Darwish^1,4, Shawna Kinsella^1,5, Sami Jelijeli^1,5, Vicky Goh^6,7, and Radhouene Neji¹

¹Imaging physics and engineering research department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ²Siemens Healthcare SAS, Courbvoie, France, ³Siemens Healthcare Ltd, London, United Kingdom, ⁴Research & Clinical Translation, Magnetic Resonance, Siemens Healthineers AG, Erlangen, Germany, ⁵PET Centre, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ⁶Cancer imaging research department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ⁷Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom

Synopsis

Keywords: Diffusion Acquisition, Diffusion Acquisition

Motivation: 3D quantitative T2 and ADC mapping in a single sequence could offer improved reproducibility, resolution, geometric-fidelity and image registration for prostate MRI compared to standard qualitative 2D T2 and diffusion-weighted imaging.

Goal(s): To develop a 3D distortion-free technique for T2 and ADC mapping in the prostate within a single acquisition.

Approach: A 3D distortion-free T2 and diffusion-prepared reduced-FOV sequence was developed. T2 and ADC values were compared between proposed and conventional sequences acquired in the prostate of a healthy volunteer.

Results: Images acquired with the proposed sequence were free from artefacts and exhibited T2 and ADC values comparable in range to conventional acquisitions.

Impact: This work introduces a streamlined single-sequence acquisition for 3D distortion-free T2 and ADC mapping in the prostate which may enable the development of an efficient and robust quantitative single-acquisition prostate MRI screening programme.

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