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Abstract #2161

Single-shot Center-Overlapped EPI for distortion-frEe diffusion MRI (SCOPE)

Qiang Liu1,2, Berkin Bilgic3,4,5, Deniz Erdogmus2, Lipeng Ning1, and Yogesh Rathi1
1Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, 2College of Engineering, Northeastern University, Boston, MA, United States, 3Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, 4Department of Radiology, Harvard Medical School, Boston, MA, United States, 5Harvard/MIT Health Sciences and Technology, Cambridge, MA, United States

Synopsis

Keywords: Diffusion Acquisition, Acquisition Methods

Motivation: Single-shot EPI is prone to image distortion from B0 inhomogeneity and long echo time (TE), especially in diffusion MRI (dMRI).

Goal(s): This study proposes a novel single-shot center-overlapped EPI readout, termed SCOPE, designed for distortion-free dMRI by correcting B0-induced distortions in each diffusion direction and reducing TE.

Approach: SCOPE uses two overlapped k-space segments with opposing blip directions to derive ∆B0 maps directly from single-shot data, eliminating the need for additional acquisitions. The sequence was tested in vivo on 3T.

Results: The SCOPE sequence produced high-fidelity dMRI images with minimal distortion, achieving effective distortion correction comparable to TOPUP-processed images.

Impact: We proposed a novel single-shot center-overlapped EPI readout for distortion-free EPI, SCOPE. With overlapped segments, our method estimates the ∆B0 field map from the single-shot data for each diffusion direction. Further, our method has the potential to reduce the TE.

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Keywords