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Abstract #2163

Localized diffusion pore imaging (DPI) of different pore sizes

Lucas Oswald1,2, Julian Rauch1, Pablo Javier Jimenez1,2, Mark Edward Ladd1,2,3, Frederik Bernd Laun4, and Tristan Anselm Kuder1,2
1Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Faculty of Physics and Astronomy, Heidelberg University, Heidelberg, Germany, 3Faculty of Medicine, Heidelberg University, Heidelberg, Germany, 4Institute of Radiology, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany

Synopsis

Keywords: Diffusion Acquisition, New Signal Preparation Schemes, Diffusion pore imaging

Motivation: MRI diffusion pore imaging (DPI) is a potentially powerful tool for non-invasive pathological examinations. Average pore sizes and shapes can be reconstructed using modified diffusion measurements.

Goal(s): As pore imaging relies on averaging over pores in regions of interest to go beyond the resolution of classical MR imaging, in-vivo applications require the combination of DPI with conventional MR imaging to estimate the pore sizes in those regions.

Approach: A conventional spin-echo imaging sequence was combined with a pore imaging sequence to measure a phantom containing capillaries.

Results: We successfully reconstructed different pore sizes at different locations from a single DPI measurement.

Impact: Localized diffusion pore imaging allows reconstructing several pore sizes in different regions from a single sample. This was achieved using a diffusion pore imaging sequence with imaging readout and a phantom containing capillaries of two different sizes.

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Keywords