Keywords: Diffusion Modeling, Diffusion Modeling, endometrial carcinoma; benign endometrial lesion; comparative study
Motivation: Accurately differentiating benign and malignant endometrial lesions is essential given the implications for management and prognosis.
Goal(s): Accurately differentiating benign and malignant endometrial lesions is essential given the implications for management and prognosis.
Approach: Clinical indicators and 14 diffusion parameters derived from monoexponential diffusion-weighted imaging (DWI), diffusion kurtosis imaging (DKI), intra-voxel incoherent motion (IVIM), stretched exponential model (SEM), continuous-time random walk (CTRW), and fractional order calculus (FROC) models were calculated and assessed.
Results: MK, D, and αCTRW could be independent predictors of early EC, and their performance could be improved by combining them with the menopause parameter.
Impact: Together, diffusion parameters and the combined model could become a new and non-invasive diagnostic biomarker for differentiating benign and malignant endometrial lesions.
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