Keywords: DWI/DTI/DKI, Breast
Motivation: Advanced diffusion models can assess the Ki67 expression (≤ 5% and ≥ 30%), aiding in the clinical treatment decision for ER+/HER2- breast cancers.
Goal(s): This study investigated the first-order features extracted from conventional DWI, diffusion kurtosis imaging (DKI), fractional order calculus (FROC), and continuous-time random walk (CTRW) in discriminating Ki67 expression status.
Approach: Retrospective study analyzed nine diffusion parameters derived from DWI, DKI, FROC and CTRW in 121 patients divided into low, medium and high Ki67 groups; utilized AUC and logistic regression for status prediction.
Results: The FROC model could help identify the low Ki67expression (≤ 5%) and prevent unnecessary chemotherapy.
Impact: This research reveals the utilization of FROC model improved differentiation of the low Ki67 expression group (Ki67≤ 5%) in ER+/HER2- breast cancer, who frequently exhibit a favorable prognosis and do not require excessive adjuvant chemotherapy.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords