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Abstract #2181

Quantitative Susceptibility Mapping to Measure Focused Ultrasound-Mediated Delivery of Size-Variable Model Drugs to the Brain

Matthew Hoch1, Timothy Ho1, Richard Price1, and Grady Miller1,2
1Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, 2Radiology, University of Virginia, Charlottesville, VA, United States

Synopsis

Keywords: MR-Guided Focused Ultrasound, Brain

Motivation: We lack a quantitative MRI method to investigate the effect of molecular size on the delivery profile of a model drug in focused ultrasound (FUS)-mediated blood-brain barrier disruption (BBBD).

Goal(s): Demonstrate that quantitative susceptibility mapping (QSM) is capable of measuring the delivery of size-varied paramagnetic contrast agents in FUS-mediated BBBD.

Approach: Utilize FUS to deliver paramagnetic contrast agents to the striatum of healthy mice, employing QSM to quantify and convert susceptibility changes to agent concentration.

Results: Our work demonstrates that QSM is capable of measuring the 3D, in-vivo distribution of large-scale contrast agents after FUS-mediated BBB disruption with high spatial resolution.

Impact: This study offers a new tool to measure the FUS-mediated delivery of molecules within the size range of common neurotherapeutics, enabling both clearer interpretation of therapeutic outcomes and size-specific dosage and treatment planning in both pre-clinical and clinical settings.

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Keywords