Keywords: MR-Guided Focused Ultrasound, Brain
Motivation: We lack a quantitative MRI method to investigate the effect of molecular size on the delivery profile of a model drug in focused ultrasound (FUS)-mediated blood-brain barrier disruption (BBBD).
Goal(s): Demonstrate that quantitative susceptibility mapping (QSM) is capable of measuring the delivery of size-varied paramagnetic contrast agents in FUS-mediated BBBD.
Approach: Utilize FUS to deliver paramagnetic contrast agents to the striatum of healthy mice, employing QSM to quantify and convert susceptibility changes to agent concentration.
Results: Our work demonstrates that QSM is capable of measuring the 3D, in-vivo distribution of large-scale contrast agents after FUS-mediated BBB disruption with high spatial resolution.
Impact: This study offers a new tool to measure the FUS-mediated delivery of molecules within the size range of common neurotherapeutics, enabling both clearer interpretation of therapeutic outcomes and size-specific dosage and treatment planning in both pre-clinical and clinical settings.
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