Keywords: MR-Guided Focused Ultrasound, Focused Ultrasound, head phantom; tumor simulator; T2-W TSE imaging; MR thermometry; robotic system
Motivation: A literature gap remains for realistic tissue phantoms featuring tumor simulators, especially in their application for evaluating Magnetic Resonance Imaging (MRI)-guided Focused Ultrasound (MRgFUS) ablation protocols.
Goal(s): This study aimed to improve existing research by introducing a special tumor-bearing head phantom and examining the feasibility of tumor ablation through 1-mm skull mimics.
Approach: Robotic assisted sonications of the tumor simulator were conducted in a 3T MRI scanner, with FUS-induced thermal effects monitored through thermometry and high-resolution imaging.
Results: Hyperintense lesions were observed within the tumor mimic, achieving complete tumor coverage in both free-field conditions and with a Resin skull in place.
Impact: This research provides initial insights into utilizing a thin, biocompatible implant to temporarily replace a segment of the skull, enabling MRgFUS ablation of inoperable brain tumors with a single-element transducer and presenting potential clinical benefits, pending further feasibility studies.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords