Keywords: MR-Guided Interventions, Preclinical, Liver, microwave ablation, Oncopig, clinical workflow
Motivation: MR thermometry can monitor microwave ablation (MWA) and predict ablation zones, but it's prone to image quality degradation during MWA and lacks validation for predicted ablation zone dimensions.
Goal(s): 1) Develop a real-time MR thermometry technique for monitoring MWA; 2) validate the MR thermometry-predicted ablation zone with immediate post-ablation MRI and gross pathology in a preclinical model.
Approach: MRI-guided MWA with a respiratory-triggered MR thermometry sequence was performed in two Oncopigs with induced liver tumors.
Results: MR thermometry can monitor MWA without noticeable artifacts. Thermometry-predicted ablation zones were in general agreement with post-ablation MRI and gross pathology.
Impact: The experimental setup using the Oncopig cancer model demonstrates a promising preclinical framework for developing, validating, and refining MR thermometry techniques to improve MRI-guided MWA for better outcomes.
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