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Abstract #2196

Monitoring accurate MR guided focused ultrasound hyperthermia treatments with a k-space based B0 correction thermometry technique

Sara L Johnson1, Benjamin Nelson2, Patricia Guenkawa3, Erik Dumont4, John Roberts3, Dennis Parker1, Henrik Odéen3, and Allison Payne1
1Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States, 2Computer Science, University of Utah, Salt Lake City, UT, United States, 3University of Utah, Salt Lake City, UT, United States, 4Image Guided Therapy, Pessac, France

Synopsis

Keywords: Thermometry/Thermotherapy, Thermometry/Thermotherapy

Motivation: Accurate MR thermometry methods are critical to the successful delivery of hyperthermia thermal therapy treatments.

Goal(s): Evaluate a k-space based B0 correction technique for MR thermometry in MR guided focused ultrasound hyperthermia treatments.

Approach: The performance of a previously developed thermal controller was evaluated using 3D PRF MR thermometry both with and without k-space field drift correction in phantom and in vivo rabbit undergoing MRgFUS hyperthermia treatment. The MRTI precision was also evaluated in a single human subject under non-heating conditions.

Results: Drift corrected MRTI improved targeting accuracy of a PID controlled hyperthermia treatment in both phantoms and rabbits.

Impact: Accurate MR thermometry is critical to the successful delivery of hyperthermia treatments, where a fraction of degree accuracy can impact treatment outcome. Implementing a k-space based B0 correction technique achieves substantially improved accuracy in MR guided focused ultrasound hyperthermia treatments.

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Keywords