Abstract #2198

Porcine liver machine perfusion under MRI to study the influence of hepatic arterial blood flow on microsphere distribution in radioembolization

Tess J. Snoeijink^1,2, Anne van den Brekel¹, Jan L. van der Hoek², Jaap G.M. Greve³, H. Remco Liefers³, Milou Boswinkel¹, Simeon J.S. Ruiter⁴, Erik Groot Jebbink², and J. Frank W. Nijsen¹

¹Department of Medical Imaging, Radboud University Medical Centre, Nijmegen, Netherlands, ²Multi-Modality Medical Imaging Group, TechMed Centre, University of Twente, Enschede, Netherlands, ³TechMed Simulation Centre, University of Twente, Enschede, Netherlands, ⁴Department of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, University Medical Centre Groningen, University of Groningen, Groningen, Netherlands

Synopsis

Keywords: Other Interventional, Ex-Vivo Applications, Blood vessels, treatment

Motivation: Patients undergoing transarterial radioembolization (TARE) present with a broad range of hepatic arterial (HA) blood flows. Whether the HA blood flow affects the distribution of microspheres remains unknown.

Goal(s): To investigate the influence of HA blood flow on microsphere distribution via an MRI-compatible ex vivo porcine liver machine perfusion set-up.

Approach: Paramagnetic holmium microspheres were injected in the HA under varying arterial blood flow conditions. Holmium-sensitive T2*-weighed MRI scans were acquired to study the microsphere distribution.

Results: The MRI-based dose maps revealed more homogenous distribution patterns for higher HA flows compared to lower flows.

Impact: Our ex vivo porcine liver perfusion setup under MRI provides an unique platform to assess the influence of patient-specific parameters during TARE. This platform may also contribute to the detailed study of various liver diseases and potential treatments under MRI.

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