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Abstract #2202

Quantitative 3D T1ρ Imaging for Monitoring Radiotherapy Treatment Response in Cervical Cancer

Sandeep Panwar Jogi1, Vonetta Williams2, Qi Peng3, Ricardo Otazo1,4, Marisa Kollmeier2, Victoria Yu1, and Can Wu1
1Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 2Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 3Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States, 4Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States

Synopsis

Keywords: MR-Guided Radiotherapy, Cancer, T1rho, Cervical Cancer, Chemoradiation therapy, Treatment response, Relaxometry

Motivation: Early assessment of the response to concurrent chemoradiation therapy (CCRT) is crucial for the effective management of cervical cancer.

Goal(s): To evaluate the response to CCRT in cervical cancer using quantitative 3D T1ρ imaging.

Approach: 3D T1ρ imaging was performed on four cervical cancer patients before treatment and weekly during the five-week treatment period. The T1ρ values of the tumors were evaluated to monitor treatment response.

Results: Significant decreases in T1ρ values in the tumors were observed starting in week 2 (4.91% decrease) and week 3 (18.81% decrease) during the five-week treatment.

Impact: This study demonstrates the feasibility of using quantitative 3D T1ρ imaging to assess the response to concurrent chemoradiation in cervical cancer. T1ρ imaging can provide complementary information to help predict treatment response at early timepoints during chemoradiation to individualize treatment.

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