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Abstract #2207

Inter-fractional Size Change of Lymph Node Metastases during MR-guided Stereotactic Body Radiotherapy in Oligometastatic Prostate Cancer

Jing Yuan1, Cindy Xue1, Oi Lei Wong1, Darren MC Poon2, Bin Yang3, and Sin-Ting Chiu4
1Research Department, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong, 2Comprehensive Oncology Centre, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong, 3Medical Physics Department, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong, 4Radiotherapy Department, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong

Synopsis

Keywords: MR-Guided Radiotherapy, MR-Guided Radiotherapy, oligometastatic prostate cancer

Motivation: MDT is promising for oligometastatic prostate cancer(omPC) and could have potential for better management of lymph node metastases(LNMs) through the use of MR-guided radiotherapy (MRgRT).

Goal(s): The primary goal is to quantitatively assess inter-fractional size changes of irradiated LNMs during MRgRT and evaluate their clinical implications for treatment adaptation.

Approach: We analyzed 42 LNMs across 14 patients, measuring size changes via daily MRI scans during a 5-fraction MRgSBRT treatment regimen.

Results: Results showed a significant trend of size reduction in most LNMs, with 57.1% of patients exhibiting substantial changes that influenced online treatment adaptations, suggesting potential prognostic value for MRgSBRT outcomes.

Impact: The study's findings could enhance clinical practices in managing LNMs in omPC, prompting further investigations into the prognostic value of inter-fractional size changes. This research may lead to improved treatment strategies and personalized approaches, ultimately benefiting patient outcomes.

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