Abstract #2219

Using quantitative T1rho mapping on extraocular muscles for assessing activity of thyroid-associated orbitopathy: preliminary observation

Ziqin Zhou^1,2, Min Deng¹, Ziqiang Yu¹, Joanna Ka Man Ng³, Karen Kar Wun Chan⁴, Kelvin Kam Lung Chong⁴, Weitian Chen¹, and Winnie Chiu Wing Chu¹

¹Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ²MR Research Collaboration, Siemens Healthineers, Hong Kong, Hong Kong, ³Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁴Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong

Synopsis

Keywords: Muscle, biomarkers, Orbit MRI, spin-lock, T1rho, TAO

Motivation: Quantitative T1rho mapping holds promise in evaluating inflammatory myopathies, while its diagnostic performance in assessing extraocular muscles (EOM) involved in thyroid-associated orbitopathy (TAO) remains uncertain.

Goal(s): To explore the utility of quantitative T1rho mapping in active TAO.

Approach: T1rho imaging was performed on 20 active TAO patients and 12 healthy volunteers. The T1rho value of bilateral medial rectus and lateral rectus was measured and compared with T2.

Results: T1rho of EOMs of active TAO patients increase significantly when compared to healthy volunteers. Quantitative T1rho mapping shows improved diagnosis performance in TAO than T2 mapping with a 10-fold reduction of total scanning time.

Impact: First implementation of quantitative T1rho mapping in orbit MRI to evaluate TAO-affected EOMs.

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