Meeting Banner
Abstract #2222

Multi-parametric MRI evaluation of skeletal muscle alterations using FF, T1H2O, and T2H2O in healthy and pathological subjects

Benjamin Marty1, Pierre-Yves Baudin1, Guillaume Bassez2, Teresinha Evangelista2, Tanya Stojkovic2, Sophie Olivier3, Silvana de Lucia4, Fei Cao5, Olivier Benveniste6, Yves Allenbach6, Yves Fromes1, and Harmen Reyngoudt1
1Neuromuscular Investigation Center, NMR Laboratory, Institute of Myology, Paris, France, 2Service of Neuro-Myology, Institute of Myology, Paris, France, 3Atamyo Therapeutics, Paris, France, 4Assistance Publique Hôpitaux de Paris, Institut de Myologie, I-Motion clinical trials platform, Hôpital Armand Trousseau, Paris, France, 5Généthon, Evry, France, 6Department of Internal Medicine and Clinical Immunology, Inflammatory Myopathies Reference Center, Research Center in Myology UMR974, Sorbonne Université, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière University Hospital, Paris, France

Synopsis

Keywords: Muscle, Muscle, Fat Fraction, Water T1, Water T2, Neuromuscular Diseases

Motivation: Fat fraction (FF), water T2 (T2H2O) and water T1 (T1H2O) are used to evaluate muscle tissues. It remains unclear whether their combination may provide further insight into muscle tissue characterization.

Goal(s): We investigated the relationship between these variables and explored how their combination identifies muscle clusters differentiating various conditions.

Approach: We analyzed five muscles groups in healthy and diseased subjects from which we extracted 15 features and performed k-means clustering.

Results: Six muscle clusters were identified: muscles from healthy controls were classified in 2 clusters, while the remaining were found only in patients. The correlation between T1H2O and T2H2O differed between muscle clusters.

Impact: FF, T1H2O and T2H2O are sensitive biomarkers for detecting muscle alterations. Their combination allows categorizing muscles into clusters which may reflect different underlying pathological processes. This approach holds promise for improving patient phenotyping and enhancing diagnostic precision in neuromuscular diseases.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Abstract

Keywords