Abstract #2229

Exploring the Impact of Electroconvulsive Therapy on Glymphatic System Function in First-Episode Major Depressive Disorder

Kyohma Wada¹, Keita Watanabe¹, Kentaro Akazawa¹, Enkmurun Chibaatar², Naomichi Okamoto², Patrick M. Quinn³, Atsuko Ikenouchi², Takahiro Shinkai², Shingo Kakeda⁴, Reiji Yoshimura², and Kei Yamada¹

¹Department of Radiology, Kyoto Prefectural University of Medicine, Kyoto, Japan, ²Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan, ³Wakamatsu Hospital, University of Occupational and Environmental Health, Kitakyushu, Japan, ⁴Department of Radiology, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan

Synopsis

Keywords: Psychiatric Disorders, Neurofluids

Motivation: This study is motivated by the need to understand whether electroconvulsive therapy (ECT) affects the glymphatic system in treating major depressive disorder (MDD).

Goal(s): The goal is to determine whether ECT affect the volume of lateral ventricle and choroid plexus, which reflect the glymphatic system.

Approach: Using structural MRI, we analyzed volumetric changes between pre- and post-ECT in first-episode, drug-naïve MDD patients.

Results: Lateral ventricular volume changes were greater than those in other brain structures and statistically significantly correlated with clinical improvements in MDD following ECT.

Impact: This study is the first to demonstrate glymphatic system improvements from ECT, enhancing our understanding of its therapeutic mechanisms in major depressive disorder. These insights could guide more targeted and effective interventions for treating patients with major depression disorders.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.