Keywords: Psychiatric Disorders, fMRI (resting state)
Motivation: Subthreshold depression (StD) as a transitional stage of depression, identifying biological markers of StD is essential to prevent depression.
Goal(s): To investigate the relationship between brain function, inflammatory cytokines, and symptoms in StD.
Approach: Multiple linear regression was adopted to model the relationship between functional connectivity (FC) values, psychological variables and pro-inflammatory cytokines levels of StD.
Results: The interaction of Interleukin-1β (IL-1β) level × FC values in anterior cingulate cortex (ACC) - superior frontal gyrus (SFG) was an independent predictor for the anxiety scores in StD. The interaction of Interleukin-17 (IL-17) × FC in ACC - SFG was an independent predictor for the rumination scores.
Impact: It is suggested that StD may have the tendency of autoimmune dysfunction. We hypothesize that IL-1β and IL-17 may show synergistic effects in inflammatory response and immune regulation, which co-influencing the FC of ACC-SFG, causing rumination and anxiety.
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