Abstract #2238

Investigating the Association Between Water Exchange Across the Blood–Brain Barrier and Depressive Symptoms in Major Depressive Disorder

Yao Ge¹, Lijuan Chen¹, Yu Shen¹, Zhaoqing Li², Yifan Zhang³, Dingsheng Shi³, Yan Bai¹, Wei Wei¹, Xianchang Zhang⁴, Kaixin Li⁴, Ruiliang Bai⁵, and Meiyun Wang^1,6

¹Department of Radiology, Zhengzhou University People's Hospital & Henan Provincial People's Hospital, Zhengzhou, China, ²Department of Physical Medicine and Rehabilitation of the Affiliated Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China, ³Key Laboratory of Biomedical Engineering of Education Ministry, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China, ⁴MR Research Collaboration, Siemens Healthineers Ltd., Beijing, China, ⁵Interdisciplinary Institute of Neuroscience and Technology, Zhejiang University School of Medicine, Hangzhou, China, ⁶Biomedical Research Institute, Henan Academy of Sciences, Zhengzhou, China

Synopsis

Keywords: Psychiatric Disorders, Brain, water exchange, Blood-brain barrier

Motivation: Although previous studies have demonstrated that blood-brain barrier (BBB) dysfunction plays a crucial role in the pathophysiology of depression, current neuroimaging techniques require the use of exogenous contrast agents, which limits their application in major depressive disorder (MDD) patients.

Goal(s): This study aims to investigate the relationship between water exchange across the BBB and clinical status in patients with MDD.

Approach: We conducted a comparative analysis of apparent exchange rates across the BBB, and assessed their correlations with MADRS and HAMD scores.

Results: This study revealed increased water exchange rate across the BBB in patients with MDD, which correlated significantly with symptom severity.

Impact: This research advances our understanding of the relationship between blood-brain barrier permeability and major depressive disorder, potentially providing new insights into depression's biological mechanisms and identifying novel therapeutic markers.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.