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Abstract #2240

Neuroendocrine Mechanisms in Major Depressive Disorder: A Resting-State fMRI Study on ACTH-Related Brain Network Changes

Shiyun Tian1, Chun Yang1, Wei Du1, and Yanwei Miao1
1the First Affiliated Hospital of Dalian Medical University, Dalian, China

Synopsis

Keywords: Psychiatric Disorders, Psychiatric Disorders

Motivation: Major depressive disorder (MDD) patients often show varying levels of adrenocorticotropic hormone (ACTH), suggesting distinct neurobiological mechanisms.

Goal(s): This study aimed to investigate resting-state brain connectivity in MDD patients with different ACTH levels.

Approach: We analyzed functional connectivity from fMRI scans of 49 MDD patients and 21 healthy controls, stratifying participants based on ACTH levels.

Results: Higher ACTH MDD patients displayed decreased global connectivity indicators and extensive connectivity changes compared to normal-ACTH patients, indicating distinct topological patterns related to HPA axis functionality.

Impact: These findings suggest that MDD patients with varying ACTH levels exhibit unique brain network alterations, potentially informing neurobiological mechanisms and treatment strategies for hormone-related depression.

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Keywords