Abstract #2245

White Matter Integrity Differences in Children Treated with Extracorporeal Membrane Oxygenation: A Tract-Based Spatial Statistics Analysis

Michaela Ruttorf^1,2, Thomas Schaible³, Meike Weis⁴, and Frank Gerrit Zoellner^1,2

¹Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ²Mannheim Institute for Intelligent Systems in Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ³Department of Neonatology, University Medical Centre Mannheim, Mannheim, Germany, ⁴Department of Radiology and Nuclear Medicine, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

Synopsis

Keywords: Neuro, White Matter, Tract-based Spatial Statistics, Neurodevelopmental imapirment, children

Motivation: The diagnosis of neurodevelopmental impairment in children treated with extracorporeal membrane oxygenation (ECMO) as neonates heavily relies on neuropsychological assessments which are highly subjective and present challenges for early diagnosis and intervention.

Goal(s): The purpose of this study was to investigate the changes in white matter microstructure in 2-year old children treated with ECMO as neonates.

Approach: We used a diffusion-weighted imaging (DWI) based TBSS approach to analyse the whole brain.

Results: Our findings indicate white matter changes in multiple brain regions among children treated with ECMO as neonates. Additionally, these brain regions correlated with results from neuropsychogical testings reported in literature.

Impact: Analysing diffusion measures can help to detect early microstructural changes in the brain of children treated with ECMO as neonates making it a promising tool for focused screening to support therapeutic strategies or targeted training to mitigate neurodevelopmental deficits.

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