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Abstract #2248

Structural connectivity changes of primary motor cortex after TMS in cerebral palsy assessed by DTI and non-negative matrix factorization

Yitong Bian1, Zhichen Wei1, Zhen Jia1, Liang Wu1, Tianjiao Chen1, Jian Yang1, and Xianjun Li1
1The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

Synopsis

Keywords: Neuro, Brain Connectivity

Motivation: Spastic cerebral palsy (SCP) causes motor dysfunction due to brain damage, with TMS as a potential therapeutic tool. The effects of TMS on structural connectivity remain poorly understood.

Goal(s): To evaluate structural connectivity changes in the precentral gyrus of children with SCP before and after TMS treatment using DTI and non-negative matrix factorization (NMF).

Approach: Three children with SCP underwent MRI scans before and after a 4-week TMS course. Connectivity changes were analyzed using DTI, probabilistic tractography, and NMF.

Results: TMS treatment enhanced structural connectivity in the injured hemisphere, suggesting cortical reorganization, with no significant changes in the unaffected hemisphere.

Impact: This study demonstrates that TMS induces structural reorganization in the precentral gyrus of children with spastic cerebral palsy, offering insights into its potential as a targeted neuroplasticity-driven therapeutic approach for motor function improvement.

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