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Abstract #2251

Neurovascular Coupling Alterations in Language and Visual Processing Regions in Children with Spastic Cerebral Palsy: An rs-fMRI and ASL Study

Haoyue Yu1, Yu Luo1, Chunfeng Zhao1, Lisha Nie2, Ying Peng1, Dan Luo1, Yu Yin3, Haifeng Ran1, and Heng Liu1
1Department of Radiology, Affiliated Hospital of Zunyi Medical University, Zunyi, China, 2GE HealthCare MR Research, Beijing, China, 3Department of Radiology, the Second Xiangya Hospital of Central South University, Changsha, China

Synopsis

Keywords: Neuro, Arterial spin labelling, Neurovascular coupling

Motivation: The relationship between cerebral blood flow (CBF) and neural activity, or neurovascular coupling (NVC), in spastic cerebral palsy (SCP) remains unclear, particularly its role in language and visual impairments.

Goal(s): This study aims to investigate specific NVC disruptions in SCP to better understand associated cognitive and communication deficits.

Approach: Twenty SCP children and 27 healthy controls underwent resting-state fMRI and arterial spin labeling to calculate regional NVC ratios, including CBF/fALFF, CBF/ALFF, CBF/ReHo, and CBF/DC.

Results: SCP children exhibited significant NVC disruptions, with reduced coupling in the superior temporal gyrus and increased coupling in the calcarine and lingual gyri.

Impact: This study identifies distinct NVC patterns in SCP, providing potential biomarkers for assessing disease severity and guiding targeted interventions for SCP-related impairments.

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Keywords