Abstract #2257

The Targeted 1H MRS of Methylmalonic Acid and Lactate In Vivo

Mengyuan Zhuo¹, Yan Yun², Jiaxiang Xin³, Yufan Chen⁴, Yang Zhao⁴, Tao Gong⁴, Xuewen Xing⁴, Fei Liu⁴, Yuxin Li⁴, Yao Zou⁵, and Guangbin Wang^1,4

¹Shandong University, Jinan, China, ²Shandong University QILU Hospital, Jinan, China, ³MR Research Collaboration, Siemens Healthineers Ltd, Shang Hai, China, ⁴Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, ⁵Binzhou Medical University, Jinan, China

Synopsis

Keywords: Neuro, Metabolism, Methylmalonic Acid（MMA），MRS

Motivation: Methylmalonic acidemia is an extremely harmful organic acidemia causing multi-system damage mainly in the central nervous system.

Goal(s): To selectively probe the ¹H MR signals of methylmalonic acid and lactate (Lac) in vivo in the brain of methylmalonic acidemia (MMA) patients.

Approach: The optimal J-editing ¹H MRS approach was used to probe the MMA and Lac signals in vivo.

Results: The methylmalonic acid and lactate ¹H MR signals were selectively probed in a phantom and 8 MMA patients, confirming their correlation with urine and blood concentration levels.

Impact: We successfully detected methylmalonic acid and Lac signals in MMA patients, providing crucial support for exploring MMA metabolic pathways in vivo.

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