Abstract #2259

White matter brain temperatures are associated with neurodevelopmental outcome following neonatal hypoxic ischemic encephalopathy (HIE)

Laura Adriana Malina^1,2, Barbara Brotschi³, Rahel Heule², Raimund Kottke⁴, Cornelia Hagmann³, Beatrice Latal⁵, and Ruth O'Gorman Tuura²

¹University of Zurich, Zurich, Switzerland, ²Center for MR Research, University Children's Hospital Zurich, Zurich, Switzerland, ³Neonatology and Pediatric Intensive Care,, University Children's Hospital Zurich, Zurich, Switzerland, ⁴Diagnostic Imaging, University Children's Hospital Zurich, Zurich, Switzerland, ⁵Child Development Center, University Children's Hospital Zurich, Zurich, Switzerland

Synopsis

Keywords: Neonatal, Spectroscopy

Motivation: Neonatal hypoxic ischemic encephalopathy (HIE) is a leading cause of death and neurological impairment. Therapeutic hypothermia improves outcomes, especially in moderate to severe HIE. An elevated core body temperature represents a risk factor for adverse outcome. The link between brain temperature and outcome following HIE has not yet been explored.

Goal(s): To examine the link between brain temperature and neurodevelopmental outcome in HIE.

Approach: Regression analysis comparing white matter (WM) and basal ganglia (BG) brain temperatures from MRS to neurodevelopmental outcome.

Results: WM but not BG brain temperatures correlated significantly with the Bayley Scales of Infant and Toddler Development III at age 2.

Impact: In infants with HIE, WM brain temperatures from MRS correlate with motor, cognitive, and language outcomes at 2 years. WM brain temperatures represent a promising marker for outcome, aiding parent counselling and early identification of patients needing additional support.

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