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Abstract #2265

Magnetization Transfer Imaging of the Lung at 0.55T

Alexandra Braun1,2, Grzegorz Bauman1,2, and Oliver Bieri1,2
1Department of Biomedical Engineering, University of Basel, Allschwil, Switzerland, 2Department of Radiology, Division of Radiological Physics, University Hospital Basel, Basel, Switzerland

Synopsis

Keywords: Lung, Magnetization transfer, Low Field, bSSFP

Motivation: Very little is known about magnetization transfer (MT) effects of the lung and MT contrast might be a biomarker for pulmonary fibrosis and other lung tissue abnormalities.

Goal(s): To develop a clinically applicable method for detecting in-vivo MT contrast in the lung.

Approach: A self-gated 3D half-radial balanced steady state free precession sequence (bSTAR) in combination with RF pulse prolongation was used to explore MT effects in the lung at 0.55T.

Results: In volunteers, average whole lung MTR values of 32.4 ± 3.5 [pu] were observed and showed good reproducibility.

Impact: This work shows that high-resolution in-vivo magnetization transfer imaging of the lung is feasible and reproducible at 0.55T in free-breathing and within clinically relevant scan times, offering excellent prospects to detect lung tissue abnormalities such as fibrosis.

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