Keywords: Lung, Magnetization transfer, Low Field, bSSFP
Motivation: Very little is known about magnetization transfer (MT) effects of the lung and MT contrast might be a biomarker for pulmonary fibrosis and other lung tissue abnormalities.
Goal(s): To develop a clinically applicable method for detecting in-vivo MT contrast in the lung.
Approach: A self-gated 3D half-radial balanced steady state free precession sequence (bSTAR) in combination with RF pulse prolongation was used to explore MT effects in the lung at 0.55T.
Results: In volunteers, average whole lung MTR values of 32.4 ± 3.5 [pu] were observed and showed good reproducibility.
Impact: This work shows that high-resolution in-vivo magnetization transfer imaging of the lung is feasible and reproducible at 0.55T in free-breathing and within clinically relevant scan times, offering excellent prospects to detect lung tissue abnormalities such as fibrosis.
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