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Abstract #2267

Respiration Monitoring with Remote Pneumatic Dose Administration for 129Xe MRI

Drew Clements1, Suphachart Leewiwatwong2, Anna Costelle2, Andrew McHorse2, Seth Lee2, Cody Blanton1, Jennifer Korzekwinski1, Alex Sents1, Jean Shaffer1, Sarah Harris1, David Mummy1,2, and Bastiaan Driehuys1,2
1Department of Radiology, Duke University Medical Center, Durham, NC, United States, 2Department of Biomedical Engineering, Duke University, Durham, NC, United States

Synopsis

Keywords: Lung, Hyperpolarized MR (Gas), Repeatability, Lung Inflation, Xenon, Gas Exchange

Motivation: Repeatability of hyperpolarized 129Xe MRI measurements is dependent on lung inflation volume. Currently, there is no standard for respiration coaching or dose delivery.

Goal(s): Determine the variables that affect lung inflation during 129Xe MRI to standardize best practices for coaching and dose delivery and maximize scan repeatability.

Approach: Create a device to measure subject respiratory patterns and remotely deliver hyperpolarized 129Xe in the MRI bore. Determine the aspects of coaching and dose delivery that affect lung inflation.

Results: Subjects appear to change their inhalation volumes and flow rates when dose coaching begins, resulting in variable starting lung volumes.

Impact: Monitoring subject respiration prior to hyperpolarized 129Xe administration reveals altered respiration patterns. This work will inform new approaches for consistent subject coaching and dose delivery to improve repeatability of lung inflation during imaging.

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