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Abstract #2270

Comparison of Inert Fluorinated Gas and Hyperpolarized 129Xe Lung MRI Image Quality in Pediatric Participants

Brandon Zanette1, Faiyza S Alam1,2, Felix Ratjen3,4, and Giles Santyr1,2
1Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada, 2Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3Translational Medicine, The Hospital for Sick Children, Toronto, ON, Canada, 4Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada

Synopsis

Keywords: Lung, Lung, 19F, Fluorine-19, Ventilation, Perfluoropropane, Hyperpolarized 129Xe, Xenon-129, Pediatrics, Cystic Fibrosis

Motivation: Inert fluorinated gas MRI with perfluoropropane (PFP-MRI) holds potential as a lower cost alternative to hyperpolarized xenon MRI (Xe-MRI). However, PFP-MRI remains understudied in pediatrics with no comparisons to Xe-MRI in children.

Goal(s): To compare image quality of PFP-MRI and Xe-MRI in pediatric participants.

Approach: Same-day PFP-MRI and Xe-MRI were performed in 10 pediatric participants. Signal-to-noise ratio (SNR) and normalized signal histograms were compared between techniques.

Results: All MRI procedures were feasible and well-tolerated. SNR was significantly higher in Xe-MRI than PFP-MRI. Normalized signal histograms highlight a large degree of overlap between Xe-MRI and PFP-MRI.

Impact: PFP-MRI may offer comparable ventilation information to Xe-MRI in children with reduced costs and infrastructure complexity, despite lower SNR and resolution.

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Keywords