Abstract #2275

Exploring Brain Differences in Lung Cancer Patients with Varying Lymph Node Statuses: A Preliminary Study Based on DTI-ALPS

Xue Liu^1,2, Nan Meng², Jiayin Pan^1,2, Zhe Wang³, Yang Yang⁴, Jianmin Yuan³, and Meiyun Wang^1,2,5

¹Department of Radiology, Zhengzhou University People's Hospital, Zhengzhou, China, ²Department of Radiology, Henan Provincial People's Hospital, Zhengzhou, China, ³Central Research Institute, United Imaging Healthcare Group, Shanghai, China, ⁴Beijing United Imaging Research Institute of Intelligent Imaging, United Imaging Healthcare Group, Beijing, China, ⁵Biomedical Research Institute, Henan Academy of Sciences, Zhengzhou, China

Synopsis

Keywords: Lung, Cancer, lung cancer

Motivation: As research on lung cancer's pathological mechanisms advances, the impact of tumors on the brain has gained attention.

Goal(s): This study aims to investigate brain differences in lung cancer patients with varying lymph node statuses to address this clinical knowledge gap.

Approach: DTI-ALPS was used to analyze ALPS indexes and measure PVS volume fractions in 21 subcortical and 48 cortical regions.

Results: The Planum Temporale’s PVS volume fraction was higher in the lymph node metastasis group , while the Right Lateral Ventricle’s PVS volume fraction was lower. Additionally, the Right Lateral Ventricle’s PVS volume fraction correlated positively with ALPS indexes and negatively with Ki67.

Impact: This study offers a novel perspective on how lung cancer lymph node status impacts the central nervous system, revealing the interaction between tumor behavior and the brain, and suggesting that lymph node metastasis may affect the brain microenvironment.

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