Meeting Banner
Abstract #2277

A Novel ‘Stage-Gated’ Approach for Reporting Prostate Screening MRI: “Is Less More?”

Natasha Thorley1,2, Giorgio Brembilla 1,3,4, Francesco Giganti2,5, Tristan Barrett6, Tom Parry1, David Eldred-Evans7,8, Nikhil Mayor7,8, Alistair Lamb1, Penny Hubbard Cristinacce1, Fiona Gong1, Henry Tam9, Heminder Sokhi10,11, Anwar R Padhani11, Caroline M Moore5,12, Hashim U Ahmed7,8, and Shonit Punwani1,2
1Centre for Medical Imaging, University College London, London, United Kingdom, 2Department of Radiology, University College London Hospital NHS Foundation Trust, London, United Kingdom, 3Clinical and Experimental Radiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy, 4Vita-Salute San Raffaele University, Milan, Italy, 5Division of Surgical and Interventional Science, University College London, London, United Kingdom, 6Department of Radiology, Addenbrooke's Hospital and University of Cambridge, Cambridge, United Kingdom, 7Division of Surgery, Imperial College London, London, United Kingdom, 8Imperial Urology, Imperial College Healthcare NHS Trust, London, United Kingdom, 9Department of Radiology, Imperial College Healthcare NHS Trust, London, United Kingdom, 10Department of Radiology, The Hillingdon Hospitals NHS Foundation Trust, London, United Kingdom, 11Paul Strickland Scanner Centre, Mount Vernon Hospital, Middlesex, United Kingdom, 12Urology, University College London Hospitals NHS Foundation Trust, London, United Kingdom

Synopsis

Keywords: Prostate, MR Value

Motivation: Prostate MRI is a promising screening tool for prostate cancer, but it has a low positive predictive value (PPV), likely because assessment systems are not optimised for low disease prevalence.

Goal(s): To evaluate whether a novel two-step, ‘stage-gated’ biparametric (bp)MRI reporting approach improves the PPV compared to conventional Likert/PI-RADS scoring designed for multiparametric (mp)MRI reading.

Approach: 405 MRI scans from IP1-PROSTAGRAM underwent retrospective ‘stage-gated’ reporting: limited screening sequences (T2-weighted and b1500 diffusion-weighted images) were reviewed first, followed by the remaining bpMRI sequences if positive.

Results: The ‘stage-gated’ bpMRI approach improved the PPV compared to bpMRI Likert/PI-RADS≥4 scoring and halved the number of biopsies.

Impact: A ‘stage-gated’ reporting approach for prostate MRI screening improves the positive predictive value (PPV) compared to Likert/PI-RADS scoring while maintaining comparable cancer detection rates. This approach may prove valuable in reducing unnecessary biopsies in future prostate cancer screening trials.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Abstract

Keywords