Abstract #2282

Added value of amid proton transfer weighted MRI to PI-RADS v2.1 in differentiating clinically significant prostate cancer

Zijian Gong^1,2, Yinquan Ye^1,2, Yun Peng^1,2, Zhixuan Liu^1,2, Hongxin Ying^1,2, Jiankun Dai³, and Lianggen Gong^1,2

¹Department of Radiology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China, ²Intelligent Medical Imaging of Jiangxi Key Laboratory, Nanchang, Jiangxi, China, ³MRI research, GE Healthcare, Beijing, China, Beijing, China

Synopsis

Keywords: Prostate, Prostate, APT; MRI; prostate cancer

Motivation: It has been reported amide proton transfer (APT) weighted MRI can differentiate clinically significant prostate cancer (csPCa), but its added value to PI-RADS remains uncertain.

Goal(s): Investigating if APT weighted MRI can provide added value to PI-RADS v2.1 in diagnosing csPCa.

Approach: 134 participants were enrolled. They were additionally imaged with APT weighted MRI before pathological examination. APT and apparent diffusion coefficient (ADC) values of lesion were analyzed.

Results: APT, ADC, and PI-RADS can significantly differentiate csPCa from non-csPCa. Compared with using PI-RADS alone, the combination of APT and PI-RADS can significantly improve the diagnostic performance.

Impact: Accurately diagnosing csPCa patients is important for treatment selection. APT weighted MRI can provide significantly added value to PI-RADS v2.1 for identifying csPCa. Therefore, the application of APT weighted MRI would be beneficial for prostate cancer assessment and management.

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