Keywords: Cancer, Prostate, Pathology
Motivation: We are developing magnetic resonance histology (MRH) for surgical pathology to improve prostate cancer tissue sampling and analysis.
Goal(s): Our goal was to measure the quantitative relationships between multi-parametric MRH signal, radiomic features, and cytometric (pathology) features in clinical prostate cancer tissues.
Approach: We collected tissues from prostate cancer patients and performed high resolution MRH (40-55μm3). MRH volumes were registered to pathology at the microscopic level. Linear relationships between quantitative MRH and cytometric features were measured across the cohort.
Results: We found statistically significant linear relationships between multiple tissue cytometric features and quantitative MRH, including T2 measurements, diffusion tensor scalers, and radiomic features.
Impact: This research provides quantitative links between magnetic resonance histology and ground-truth histopathology in prostate cancer. Not only will this improve how we implement MRH for 3D pathology applications, we will also improve our interpretation of clinical prostate MRI.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords